Introduction to Genetic Association Studies
نویسندگان
چکیده
منابع مشابه
Topic Introduction Introduction to Genetic Association Studies
Genetic association studies test for a correlation between disease status and genetic variation to identify candidate genes or genome regions that contribute to a specific disease. A higher frequency of a singlenucleotide polymorphism (SNP) allele or genotype in a series of individuals affected with a disease can be interpreted as meaning that the tested variant increases the risk of a specific...
متن کاملAn Introduction to Natural Experiment Studies
در دو سخن سردبیری شماره‌های قبل به مطالعات مداخله‌ای (Interventional and/or experimental studies) [1] و مطالعات نیمه تجربی (studies Quasi-experiment) [2] پرداختیم. همان جا، به این نکته اشاره کردیم که برای اندازه‌گیری کارآیی یک دارو، واکسن، برنامه بهداشت عمومی و متغیرهای دیگری از این دست، مطالعات مداخله‌ای بهترین گزینه هستند. تقسیم تصادفی و کورسازی از مؤلفه‌های اساسی یک مطالعه مداخله‌ای است [1]....
متن کاملGenetic association studies.
To the Editor: I am delighted to see that Arteriosclerosis, Thrombosis, and Vascular Biology has taken the lead in initiating an open discussion about genetic association studies in such a prominent manner. As correctly pointed out in the editorial by Dr Hegele,1 the number of publications has exponentially increased in the last decade. Despite the intrinsic problems with this approach, this ex...
متن کاملGenetic association studies.
With the completion of the HapMap project1 and the development of technology that allows the examination of 1 million genetic polymorphisms at once, genetic association studies are becoming more comprehensive. This article first provides a brief overview of the rationale for genetic association studies; it then discusses the primary features differentiating genetic from standard association stu...
متن کاملGenetic association studies.
The widespread availability of DNA from large population studies, the development of rapid throughput genotyping assays, and the identification of numerous polymorphisms in genes of interest make it easier to perform genetic association studies in humans. We consider these studies appropriate areas of research in relation to atherosclerosis, thrombosis, and vascular biology. In this issue, Drs ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cold Spring Harbor Protocols
سال: 2012
ISSN: 1559-6095
DOI: 10.1101/pdb.top068163